Kidney Research UK

Research project grants

Name	Date	Institution	Project
Dr T Ali	2004	University of Aberdeen	Identification, classification and factors affecting the outcome of patients with sudden loss of kidney function. Research Outcome
Dr C Baigent	2004	CTSU, Oxford	Research study to assess a quick and simple method of measuring kidney function using blood obtained by a fingerprick technique. Research Outcome
Dr A H Baker	2003	University of Glasgow	Development of systemic gene delivery to the kidney. Research Outcome
Prof A Baker	2005	University of Glasgow	A novel gene therapy approach to treatment of renal disease.
Dr S Ball	2003	University Hospital Birmingham	An investigation of T cell responses to HLA-A2 peptides in dialysis patients expressing anti-HLA-A2 anitbody Research Outcome
Dr Alan Bevington	2004	University of Leicester	Designing nutritional therapy for protein wasting illness using cultured muscle cells. Research Outcome
Dr J Bradley	1999	University of Cambridge - Department of Medicine	Regulation of TNF receptors in patients undergoing renal transplantation. Research Outcome
Dr J Bradley	2004	Addenbrookes' Hospital, Cambridge.	Role of death receptor-3 in renal ischaemia-reperfusion injury. Research Outcome
Dr Colin Brown	2005	University of Newcastle.	Characterisation of drug elimination pathways in a Human Primary Culture Model of the Proximal Tubule.
Dr N Brunskill	2001	University of Leicester	Mechanisms of fatty acid induced proximal tubular dysfunction in proteinuric renal disease Research Outcome
Dr P Cockwell	2001	Queen Elizabeth Hospital, Birmingham	Natural killer cells CXCR3 and CXCLI0/1P-10 in the early activation of the renal allograft Research Outcome
Dr HT Cook	2000	Division of Medicine, Hammersmith Hospital	The role of CD40 in progressive renal scarring Research Outcome
Prof T Cook	2003	Imperial College London	Bone marrow derived stem cells and the kidney. Research Outcome
Dr G Cooper	2003	University of Sheffield	Targeting of mammalian urea transporters in the inner medullary collecting duct. Research Outcome
Dr G Cooper	2004	University of Sheffield	Structurla characterisation of the Mammalian Urea Transporters. Research Outcome
Dr S Davies	2000	North Staffordshire Hospital and Centre for Science and Technology in Medicine, Keele University	Bi-directional water flow across the dialysed peritoneum Research Outcome
Prof S Davies	2004	University of Keele	Applicatrion of body water measurement using deuterium abundance anaylsis of breath and dialysate in the individualisation of haemodialysis treatment.
Dr Debnam & Prof R Unwin	2003	Royal Free & University College Medical School, London	Active intestinal transport of phosphate in renal failure: is it a potential target in the treatment of hyperphosphateamia? Research Outcome
Dr J Domin	2001	Imperial College, London	Regulation of messangical Cell phenotype by phosphoinositol 3-kinave enzyme activity. Research Outcome
Dr L-P Erwig	2002	Institute of Medical Sciences Aberdeen	Analysis of macrophage programming in vitro and acute nephritis by cytosensors. Research Outcome
Prof S Fleming	2001	University of Dundee	Disease modifying loci and malignant hypertension Research Outcome
Dr J Goodship	2002	The Institute of Human Genetics, University of Newcastle	Genetic factors predisposing to the haemolytic uraemic syndrome Research Outcome
Prof J Goodship	2003	Institute for Human Genetics, University of Newcastle	The role of inversin in primary cilia and renal cyst formation. Research Outcome
Dr T Goodship	2003	Institute for Human Genetics, Newcastle upon Tyne	The identification of the genes responsible for atypical haemolytic uraemic syndrome. Research Outcome
Prof I Gordon	2005	Great Ormond Street Hospital, London	Reproducibility of single kidney GFR estimation using Gd DTPA enhanced MRI Research Outcome
Dr L Harper	2004	University of Birmingham	Prognostic factors predicting outcome in patients with ANCA-associated vasculitis. Research Outcome
Dr S Harper	2003	University of Bristol	The role of the novel inhibitory VEGF isoform (VEGF165 b) in the treatment of kidney cancer. Research Outcome
Prof N Hastie	2000	Western General Hospital, Edinburgh	The role of the Wilm's tumour1 (WT1) gene in the development of glomerulosclerosis Research Outcome
Dr B M Hendry	2002	King's College London	An in vitro study of the FAS antagonist farnesylthiosalicylate (FTS) in human mesangial cells Research Outcome
Dr Eric Hewitt	2004	School of Biochemistry and Microbiology, University of Leeds	Investigation into dialysis related amyloidosis (DRA): a serious complication associated with long-term renal dialysis.Research Outcome
Dr R I John	2001	Kent and Canterbury Hospital	The epidemiology of Chronic renal failure in East Kent Research Outcome
Dr T Johnson	2001	Sheffield Kidney Institute	Altered expression and Externalisation of tissues transglutaminase in relation to renal scarring Research Outcome
Dr P Kalra	2000	Hope Hospital, Salford	Investigation of the relationship between renal parenchymal disease and renal dysfunction in patients with atherosclerotic renovascular disease(ARVD) Research Outcome
Dr J Kavanagh	2001	Manchester	Identification of factors important in Urolithiasis using an in-vitro model of kidney stones formation Research Outcome
Prof J Kirby	2003	University of Newcastle	Tubulointerstitial fibrosis in chronic renal allograft dysfunction: investigation of regulation and reversibility of t cell mediated tubular epithelial to mesenchymal cell transdifferentiation. Research Outcome
Dr M Kitamura	2000	University College London	Adoptive transfer of conditionally immortalised, loss-of-function macrophages to the glomerulus: Investigation of long-term, in vivo effects of macrophages using an inbred rat strain
Dr A Lacy-Hulbert	2001	Medical School, Edinburgh	Directing conditional gene targeting in kidney cells by VP22 protein-mediated delivery of Cre recominase Research Outcome
Dr A Lemmey	2004	University of Wales, Bangor	Estimating glomerular filtration rate using measured muscle mass. Research Outcome
Dr G Lombardi	2003	Imperial College London	Anaylsis of the role played by regulatory T cells in SLE: implication for the development of cell-mediated immunotherapy. Research Outcome
Dr V Macaulay	2004	Cancer Research UK Laboratories, Weatherall Institute of Molecular Medicine, Oxford	Targeting a growth-promoting protein as treatment for kidney cancer Research Outcome
Prof A MacLeod	2000	University Of Aberdeen	Towards quality standards for the management of renal disease Research Outcome
Dr D Marples	2003	University of Leeds	Mechanisms of the modulation of antidiuresis by angiotensin and bradykinin Research Outcome
Prof P Mathieson	2001	University of Bristol	Nephrin: gene regulation and protien-protien interactions in cultured human podocytes. Research Outcome
Prof P Mathieson	2003	Southmead Hospital, Bristol	The glomerular endothelial cell and its interactions with podocytes as determinants of human glomerular permeability.Research Outcome
Dr C Miles	2003	Institute for Human Genetics, University of Newcastle	The role of mammalian -specific Wilm's tumour1 (WT1) protein isoforms in the kidney. Research Outcome
Dr A F Mooney	2003	St James University Hospital, Leeds.	Regulation of glomerular mesangial cell apoptosis by extracellular matrix. Research Outcome
Dr A Mooney	2005	University of Leeds	Role of Hic5 in regulating mesangial cell phenotype in response to extracellular matrix.
Dr R Motterlini	2004	Northwick Park Institute for Medical Research	Protection against renal dysfunction by carbon monoxide Research Outcome
Prof J Mullins	1998	University of Edinburgh	The genetic basis of hypertensive renovascular disease Research Outcome
Prof M Nicholson	2001	University of Leicester	Renal transplant preservation by normothermic pulsatile machine perfusion using a perfluorochemical based solution Research Outcome
Dr W Ouwehand	2000	University of Cambridge, East Anglia Blood Centre	Development of a biologically inactive a3(IV)NC1 antibody for specific immunotherapy in Goodpasture's disease Research Outcome
Prof. A M Peters	2002	Addenbrooke's Hospital Cambridge	Development of a "Postal Service" for measurement of glomerular filtration rate Research Outcome
Dr A Phillips	2000	University of Wales College of Medicine	Mechanisms involved in modulation of cell surface plasmin activity and their influence on activation of TGF-ß1 Research Outcome
Dr K Poulton	2001	Manchester Royal Infirmary	An investigation of the viability in kidney transplant recipient responses to immunosuppresive drugs Research Outcome
Dr L Rees	2001	Institute of Child Health, University College, London	What is the optimal range for circulating parathyroid hormone levels that maximises growth and minimises renal ostedystrophy in children with chronic renal failure? Research Outcome
Dr Lesley Rees	2005	Great Ormond Street Hospital.	The effects of calcium, phosphate and parathyroid hormone (PTH) regulation on vascular smooth muscle cell (VSMC) calcification in children with End Stage Renal Failure (ESRF) - clinical and laboratory correlation. Research Outcome
Dr D Robinson	2001	Imperial College, London	The role of Notch/Notch-ligand signaling in activity of human regulatory T cells Research Outcome
Dr L Robson	2001	University of Sheffield	Autosomal Dominant Polycystic Kidney Disease - another channelopathy Research Outcome
Dr Andrew Salmon	2006	University of Bristol	An investigation of the ability of a kidney filter derived molecule to reduce protein leakage in human kidney filters
Dr R Sandford	2000	Addenbrooke's Hospital, Cambridge	Investigation of structure-function relationships of the first PKD domain of polycystin-1 Research Outcome
Prof J Savill	1999	University of Edinburgh	Potentaition of phagocyte clearance of leucocytes undergoing apoptosis. Research Outcome
Dr J A Sayer	2002	University of Newcastle upon Tyne	Role of CLC-5 in endocytosis and crystal formation within the collecting duct Research Outcome
Dr. Claire Sharpe	2005	Kings College London	A study of the effects of Kirsten-Ras knock-down in a rat model of renal fibrosis. Research Outcome
Dr D Sheppard	1999	University of Edinburgh	Treatment of murine polycystic kidney disease using inhibitors of CFTR Research Outcome
Prof N Simmons	2004	University of Newcastle	Anaylsis of the role played by regulatory T cells in SLE: implication for the development of cell-mediated immunothRole of the ank gene in pyrophosphate transport to urine: a key mechanism to prevent intratubular crystallisation Research Outcome
Dr A Smith	2000	Leicester General Hospital	IgA nephropathy: Lymphocyte homing mechanisms and the role of Vd 3 T cells Research Outcome
Dr Ken Smith	2004	CIMR, Cambridge	Predicting the treatment response and risk of drug toxicity in autoimmune disease by the integration of clinical and genetic data.
Dr S Srai	2004	Royal Free & University College Medical School, London	Changes in intestinal iron transport in the anaemia of chronic renal failure: the role of hepcidin Research Outcome
Dr R Steadman	2003	University of Wales College of Medicine	The invitro evaluation of heparin sulphate ligosaccharides as anti-fibrotic agents. Research Outcome
Dr M Steward	2003	Iniversity of Manchester	Functional characterisation of paracellin-1 and its role in renal magnesium transport. Research Outcome
Dr G W Stewart	2003	Rayne Institute, UCL	Stomatin membrane - bound proteases and EnaC regulation in A6 cells. Research Outcome
Prof J Southgate	2004	University of York	Functional analyses of uroplakin gene mutations: implications for differentiation of the human renal tract Research Outcome
Prof R Thakker	2000	University of Oxford	Establishment of a mouse model(s) for inherited renal stone disease Research Outcome
Prof C Thiemermann	2000	London School of Medicine & Dentistry	Investigation of calapin and caspase inhibitors for the therapy of ischaemic/reperfusion injury of the kidney Research Outcome
Dr P Topham	2003	Leicester General Hospital	Mechanisms of podocyte cytoskeletal remodelling in proteinuric renal disease. Research Outcome
Dr S Tucker	2001	University Laboratory of Physiology, Oxford	Identification of Inwardly-rectifying (Kir) potassium channels in renal cortical duct cells and mechanisms which control their heteromeric assembly Research Outcome
Prof A Turner	1999	University of Edinburgh	Mechanisms of tolerance to a glomerular autoantigen Research Outcome
Prof R Unwin	1997	University College London	The application of confocal microscopy and fluorescence imaging to studies of renal tubule structure and function in vivo Research Outcome
Prof R Unwin	2001	University College London	Endosomal trafficking and the Faconi Syndrome; the relationship between megalin recyling and tubular transport dysfunction Research Outcome
Dr J Williams	2002	University of Birmingham	Ras GTPase: A pivotal role in co-operative interactions between G-protein and tyrosine kinase dependent pathways in neutrophil activation by ANCA in renal vasculitgis Research Outcome
Dr V Wilson	1997	University of Edinburgh	The role of Hefaran Sulphate-2-Sulfotransferase in kidney development Research Outcome
Dr P Winyard	2000	Institute of Child Health, London	Roles of urinary tract obstruction, PAX2 and transforming growth factor ß1 in the pathogenesis of human dysplastic kidneys. Research Outcome
Dr P Winyard	2002	Institute of Child Health, UCL	Characterising the T30H mouse model of spontaneous urinary tract maldevelopment Research Outcome
Prof A S Woolf	2002	Institute of Child Health, University College London	Angiopoetin-2 and kidney vascular development Research Outcome
Dr W Wong	2004	Guy's Hospital, London.	Cellular mechanisms responsible for chronic allograft nephropathy. Research Outcome

Senior fellowships

Training fellowships

Name	Date	Institution	Project
Dr C Bingham	2000	School of Postgraduate Medicine and Health, Exeter	The renal manifestations of hepatocyte nuclear factor-1 b mutations Research Outcome
Mr Joseph Chilcot	2006	Lister Hospital	Depression and Perception of illness among the Dialysis Population: a longitudinal Investigation.
Dr MAJ Devonald	2002	Addenbrooke's Hospital, Cambridge	Investigation of AE1 cell biology in health and disease. Research Outcome
Dr H S Dobbie	2001	Middlesex Hospital, London	The renal tubular action(s) of MEPE, a phosphoglycoprotein found in osteogenic osteomalacia and normal bone marrow. Research Outcome
Dr P Evans	2000	The Babraham Institute, Cambridge	Isolation and characterisation of protective genes in endothelial cells; pre-emption of chronic rejection of kidney allografts Research Outcome In-depth Profile
Dr RE Fielding	2003	Imperial College, London	Hepatocyte Growth Factor and nitric oxide in renal injury and repair sepsis Research Outcome
Dr D Fraser	2000	University of Wales - Institute of Nephrology	Post-transcriptional regulation of transforming growth factor b1 synthesis Research Outcome
Dr K Hillman	1999	Bland-Sutton Institute, Middlesex Hospital, London	Renal injury, P2X purinoceptor signalling and cell death Research Outcome
Dr S Jayawardene	2001	Guy's Hospital, London	Analysis of the immune response to cyclomegalovirus infection following renal transplantation. Research Outcome
Dr. L Kamesh	2002	Birmingham University	Interactions of anti-neutrophil ctyoplasmic antibodies and mannose binding lectin.
Dr KJ McDonald	2002	University of Glasgow	Role of the Fc alpha/mu receptor in IgA nephropathy. Research Outcome
Dr S Mulroy	2000	Addenbrooke's Hospital, Cambridge	Characterisation of a mouse model autosomal dominant polycystic kidney disease Research Outcome In-depth Profile
Dr J Popoola	2000	Guy's Hospital, London	Natural killer cells in transplant rejection and tolerance Research Outcome In-depth Profile
Prof A Rees	1999	University of Aberdeen	Differential effects of necrotic or apoptotic cell uptake on antigen presentation by macrophages. Research Outcome
Dr E Sharples	2004	William Harvey Research Institute, London	The role of erythropoietin in renal injury repair. Research Outcome
Dr. M Sigrist	2005	Derby City General Hospital	Determinants and cardiovascular consequences of vascular calicification in CKD patients.
Dr C Smyth	1999	Hammersmith Hospital, London	Endothelial interactions in vasculitis
Dr. MJ Stechman	2004	The Botnar Research Institue, Oxford	Characterising a genetic mouse model for renal stone disease.b mutationsResearch Outcome
Dr. AJ Streets	2003	University of Sheffield	Autosomal dominant polycystic kidney disease: regulation of polycystin interaction, trafficking and function by phosphorylation. Research Outcome
Dr N P Torpey	2001	Addenbrooke's Hospital, Cambridge	Investigation of allogenic T cell responses to vascular endothelial cell damage.
Dr D Turnberg	2002	Hammersmith Hospital, London	Complement, CD59 and renal injury Research Outcome
Dr D Ward	2002	University of Manchester	Proximal Tubular Integration of Calcium and Phosphate Homeostasis Research Outcome
Dr. DW Walbaum	2003	University of Aberdeen	Cytosensor macrophages to determine the pathways controlling macrophage anti-inflammatory functions. Research Outcome
Dr S Whitten	2001	University College Hospital, London	A clinical and molecular study of duplex kidneys Research Outcome

PhD Studentships

Name	Date	Institution	Project	Student
Prof P Mobbs	2001	University College London	The function of luminal renal tubular P2 receptors in vivo Research Outcome	Renu Vekaria
Prof C Pusey	2002	Hammersmith Hospital London	The contribution of bone marrow stem cells to renal parenchymal regeneration Research Outcome	Evangelia Prodomidi
Prof A Rees	2000	University of Aberdeen-Department of Medicine and Therapeutics	Endothelial induction of monocyte maturation into macrophages Research Outcome	Katy Hill
Prof A Rees	2000	University of Aberdeen-Department of Medicine and Therapeutics	Characterisation of cell surface receptor and gene expression as markers for the phenotypic activation of mononuclear cells.	Ann Dempster
Prof M Whitaker	2000	Medical School, Newcastle upon Tyne	How does mutation in CLC-5 cause renal stones Research Outcome	John Edward Linley
Prof GC Viberti	2002	Kings College London	Haemodynamic and metabolic factors are important in the pathophysiology of glomerular injury in diabetic nephropathy	Cecile Desspart
Prof A H Weston	2001	University of Manchester	Mechanisms of cadmium-induced apoptosis and anti-apoptosis in the kidney proximal tubule	Wing-Kee Lee
Prof A Woolf	2000	Institute of Child Health, University College London	Genetics of human kidney malformation Research Outcome	Bethan Hoskins

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