The Anaemia Clinical Study Group (CSG), sought to deliver a small pilot clinical trial to produce initial evidence on whether iron loading can reverse abnormality in heart muscle function and relieve symptoms associated with skeletal muscle impairment in chronic kidney disease (CKD) patients.
This pilot clinical study is academically-led by Professor Sunil Bhandari at Hull and East Yorkshire Hospitals NHS Trust and will involve fifty-four patients. It will be taking place over eighteen months and examine whether giving intravenous iron to patients with advanced CKD, who are iron deficient but not yet anaemic, could improve symptoms, physical agility, exercise capacity and heart function. The study will involve three UK renal units.
Depending on the outcome of this pilot study, it is envisaged that a larger randomised clinical trial would be the next step in approximately two years time.
Kidney Research UK is facilitating the management of this pilot study, with funding coming from the industrial collaborator, Pharmacosmos A/S, a company based in Denmark which is engaged in the discovery, development of products with a focus in anaemia.
Reviewed April 2019